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Related Experiment Video

Updated: Sep 4, 2025

Cancer-Associated Fibroblasts from Mouse Mammary Tumors as Tools for Molecular and Computational Studies
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A Computational Framework to Characterize the Cancer Drug Induced Effect on Aging Using Transcriptomic Data.

Yueshan Zhao1, Yue Wang1, Da Yang1,2,3

  • 1Center for Pharmacogenetics, Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA, United States.

Frontiers in Pharmacology
|July 18, 2022
PubMed
Summary

Cancer drugs can alter aging. This study integrated gene expression data to identify drugs that accelerate or protect against aging, finding specific effects for vandetanib, dasatinib, vorinostat, everolimus, and bosutinib.

Keywords:
agingcancer drugdrug-aging interactionpharmacogenomicstranscriptomics

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Area of Science:

  • Transcriptomics
  • Aging Research
  • Cancer Therapeutics

Background:

  • Cancer treatments may impact patient aging.
  • Omics data offers insights into aging's molecular changes.
  • Understanding drug-induced aging is crucial for patient care.

Purpose of the Study:

  • To computationally characterize cancer drug-induced aging using integrated transcriptomic data.
  • To identify specific aging hallmarks affected by cancer drugs.
  • To discover potential aging-accelerating and aging-protective effects of FDA-approved cancer drugs.

Main Methods:

  • Integrated normal aging and drug-induced transcriptomic datasets.
  • Utilized the GTEx dataset to validate aging-associated gene expression patterns.
  • Analyzed transcriptomic changes from 28 FDA-approved cancer drugs across multiple tissues (brain, kidney, muscle, adipose).
  • Performed drug-aging interaction analysis to identify regulated aging events.

Main Results:

  • Aging-associated gene expression in GTEx recapitulated known aging hallmarks.
  • Identified 34 potential drug-regulated aging events.
  • Vandetanib (Caprelsa®) and dasatinib (Sprycel®) showed aging-accelerating effects in brain and muscle, respectively.
  • Vorinostat (Zolinza®), everolimus (Afinitor®), and bosutinib (Bosulif®) demonstrated aging-protective effects in the brain.

Conclusions:

  • Cancer drugs can modulate aging trajectories.
  • Specific drugs exhibit distinct aging-related effects, including acceleration and protection.
  • This research provides a computational framework to assess drug-induced aging and informs therapeutic strategies.