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Related Experiment Videos

Ascorbic acid, HDL, and total plasma cholesterol in the elderly.

P F Jacques, S C Hartz, R B McGandy

    Journal of the American College of Nutrition
    |April 1, 1987
    PubMed
    Summary

    Higher plasma ascorbic acid (vitamin C) levels show a significant correlation with improved HDL cholesterol and a lower total cholesterol to HDL cholesterol ratio in older adults. The association is strongest in the 60-69 age group.

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    Area of Science:

    • Gerontology
    • Nutritional Science
    • Cardiovascular Health

    Background:

    • Ascorbic acid (vitamin C) is a vital nutrient with antioxidant properties.
    • Cholesterol levels, particularly HDL cholesterol, are critical markers for cardiovascular health.
    • Age-related changes in metabolism and nutrient levels can impact cardiovascular risk factors.

    Purpose of the Study:

    • To investigate the association between plasma and dietary ascorbic acid levels and key lipid profiles.
    • To examine the relationship between ascorbic acid and high-density lipoprotein cholesterol (HDL-C), total plasma cholesterol (T-C), and the T-C:HDL-C ratio.
    • To explore potential age-related interactions in these relationships.

    Main Methods:

    • Cross-sectional study involving 235 males and 445 females aged 60-98 years.

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  • Analysis of plasma and dietary ascorbic acid levels.
  • Statistical correlation analysis of lipid profiles (HDL-C, T-C, T-C:HDL-C ratio), accounting for covariates like age, sex, and metabolic factors.

    • Main Results:

    • Plasma ascorbic acid showed a significant positive correlation with HDL-C (r=0.09) and a negative correlation with the T-C:HDL-C ratio (r=0.10).
    • No significant correlation was found between plasma ascorbic acid and T-C (r=0.03).
    • A significant age interaction was observed, with the strongest effects of ascorbic acid on lipid profiles noted in the 60-69 year age group. Dietary ascorbic acid effects were similar but less pronounced.

    Conclusions:

    • Plasma ascorbic acid levels are significantly associated with favorable HDL cholesterol levels and cholesterol ratios in older adults.
    • The relationship between ascorbic acid and lipid profiles is influenced by age, particularly in younger-old individuals.
    • These findings suggest a potential role for adequate ascorbic acid status in maintaining cardiovascular health markers in the elderly.