Related Experiment Video
Updated: Sep 4, 2025
A Neonatal BALB/c Mouse Model of Necrotizing Enterocolitis
Published on: November 30, 2021
Association between pulmonary vein stenosis and necrotizing enterocolitis or gastrointestinal pathology: A
Jennifer Duchon1, Christiana Farkouh-Karoleski2,3, Dominique D Bailey2,4
1Division of Neonatology, BronxCare Hospital System, Grand Concourse, Bronx, New York, USA.
Objective:
Pulmonary vein stenosis (PVS) is an emerging cause of pulmonary hypertension in preterm infants. It is an often lethal condition with poor long.term prognosis and high mortality. Previous work suggests an association between necrotizing enterocolitis (NEC) and PVS, supporting a possible role for inflammatory processes due to gastrointestinal (GI) pathology as an associated risk factor for PVS.
Study Description:
We performed a matched case-control study where infants with PVS were matched for gestational age with infants without PVS. Hospital records were reviewed for prior history of NEC or other gut pathology.
Results:
Twenty-four PVS patients were matched with 68 controls; 63% of patients (15/24) had prior GI pathology as opposed to 19% (13/68) of controls. The GI pathology group had a significantly higher growth restriction and C-reactive protein. The mean gradient across the pulmonary veins was higher in the gut pathology group versus controls, as was mortality (29% vs. 9%).
Conclusions:
The previously described association between PVS and intestinal pathology was further strengthened by this study. The presence of GI pathology should lead to early surveillance and intervention for PVS.
Related Concept Videos
01:24Esophageal Varices-I: Introduction
01:29Gastroesophageal Reflux Disease I: Meaning and Pathophysiology
01:28Esophageal Perforation-II: Clinical Manifestations and Management
Clinical Manifestations:
01:29Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care
01:30Peptic Ulcer Disease I: Introduction
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
01:30Esophageal Strictures-I: Introduction
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...