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Cross-reactivity00:42

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Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...
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Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
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Related Experiment Video

Updated: Jul 9, 2026

Flow Cytometric Analysis of Particle-bound Bet v 1 Allergen in PM10
10:42

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Published on: November 19, 2016

Watermelon and ragweed share allergens.

R N Enberg, F E Leickly, J McCullough

    The Journal of Allergy and Clinical Immunology
    |June 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Allergic patients with ragweed-specific IgE antibodies often have cross-reactive IgE to gourd family members like watermelon. This cross-reactivity suggests shared allergens between ragweed and gourds, potentially causing oral allergy syndrome.

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    Area of Science:

    • Allergy and Immunology
    • Immunochemistry
    • Food Science

    Background:

    • Ragweed pollen allergy is common, and sensitization to other plant-based foods can co-occur.
    • Cross-reactivity between pollen and food allergens is a significant factor in allergic reactions.

    Purpose of the Study:

    • To investigate the prevalence of IgE antibodies against ragweed, gourd family members, and banana in allergic patients.
    • To explore potential cross-reactivity between ragweed and gourd allergens.
    • To correlate specific IgE levels with reported symptoms.

    Main Methods:

    • Biotin-avidin amplified ELISA was used to detect antigen-specific IgE in patient sera.
    • Cross-reactivity was assessed using inhibition assays and isoelectric focusing followed by immunoblotting.
    • Patients with and without specific IgE were interviewed about food-related symptoms.

    Main Results:

    • 63% of patients had anti-ragweed IgE; 28-50% of these also had IgE specific to gourd family members.
    • Significant correlations (p < 0.001) were found between ragweed and gourd-specific IgE levels.
    • Watermelon and ragweed extracts showed dose-dependent inhibition, indicating partial cross-reactivity, confirmed by shared allergen bands via immunoblotting.

    Conclusions:

    • A significant portion of ragweed-allergic individuals exhibit IgE antibodies to gourd family allergens, suggesting cross-reactivity.
    • Shared allergens between ragweed and gourds, particularly watermelon, are implicated.
    • Watermelon-specific IgE was associated with oropharyngeal symptoms, indicating a potential role in oral allergy syndrome.