Related Experiment Video
Updated: Sep 4, 2025
10:31
Three-dimensional Imaging and Analysis of Mitochondria within Human Intraepidermal Nerve Fibers
Published on: September 29, 2017
10.3K
Prohibitins: A Key Link between Mitochondria and Nervous System Diseases
Tianlin Jiang1, Jiahua Wang2, Chao Li3
1School of Medicine, Yangzhou University, Yangzhou 225001, China.
Oxidative Medicine and Cellular Longevity
|July 18, 2022
Summary
Prohibitins (PHBs) are vital proteins in cell regulation and aging. Emerging research highlights their protective role against apoptosis, inflammation, and mitochondrial dysfunction in neurological disorders.
Area of Science:
- Molecular Biology
- Neuroscience
- Cell Biology
Background:
- Prohibitins (PHBs) are conserved proteins located in mitochondria, nucleus, and cell membranes.
- PHBs are involved in critical cellular processes like cell cycle regulation, tumor suppression, and aging.
- Recent studies indicate PHBs' significant role in nervous system diseases.
Purpose of the Study:
- To review the relationship between Prohibitins and neurological disorders.
- To provide an update on the molecular mechanisms of PHBs in nervous system diseases.
Main Methods:
- Literature review of in vitro and in vivo studies.
- Analysis of molecular pathways and molecules influenced by PHBs.
Main Results:
- PHBs can prevent apoptosis, inflammation, and mitochondrial dysfunction in neurological disorders.
- Key pathways modulated by PHBs include OPA-1, PINK1/Parkin, IL6/STAT3, Tau, NO, LC3, and TDP43.
- PHBs demonstrate potential in protecting against neurodegeneration.
Conclusions:
- Prohibitins are promising therapeutic targets for neurological disorders.
- Understanding PHB mechanisms is crucial for developing neuroprotective strategies.
Related Concept Videos
01:30The Electron Transport Chain
17.2K
The electron transport chain or oxidative phosphorylation is an exothermic process in which free energy released during electron transfer reactions is coupled to ATP synthesis. This process is a significant source of energy in aerobic cells, and therefore inhibitors of the electron transport chain can be detrimental to the cell's metabolic processes.
Inhibitors of the electron transport chain
Rotenone, a widely used pesticide, prevents electron transfer from Fe-S cluster to ubiquinone or Q...
Inhibitors of the electron transport chain
Rotenone, a widely used pesticide, prevents electron transfer from Fe-S cluster to ubiquinone or Q...
17.2K
01:19Translocation of Proteins into the Mitochondria
3.2K
Mitochondrial precursors are translocated to the internal subcompartments via independent mechanisms involving distinct protein machineries called translocases.
Sorting of outer membrane proteins:
Mitochondrial outer membrane proteins are of two types: the transmembrane, beta-barrel porins, and the membrane-anchored, alpha-helical proteins. Beta-barrel porin precursors are translocated by the TOM complex and inserted into the outer mitochondrial membrane by the SAM complex. In contrast,...
Sorting of outer membrane proteins:
Mitochondrial outer membrane proteins are of two types: the transmembrane, beta-barrel porins, and the membrane-anchored, alpha-helical proteins. Beta-barrel porin precursors are translocated by the TOM complex and inserted into the outer mitochondrial membrane by the SAM complex. In contrast,...
3.2K
01:46Electron Transport Chain: Complex I and II
14.9K
The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...
ROS generation is regulated and maintained at moderate levels necessary...
14.9K
01:28Disorders of the Nervous Tissue
1.5K
Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
1.5K
01:27Protein Import into the Peroxisomes
3.6K
Cells contain membrane-bound organelles called peroxisomes that oxidize organic molecules by transferring hydrogen atoms to oxygen, producing hydrogen peroxide. Peroxisomes enzymatically convert the released hydrogen peroxide into water and oxygen.
Peroxisomal Protein Import:
Peroxisomes lack the genetic machinery required to code for their own proteins. Hence, most peroxisomal membrane, lumenal and transmembrane proteins are synthesized in the cytoplasm or ER and transported to the peroxisome...
Peroxisomal Protein Import:
Peroxisomes lack the genetic machinery required to code for their own proteins. Hence, most peroxisomal membrane, lumenal and transmembrane proteins are synthesized in the cytoplasm or ER and transported to the peroxisome...
3.6K
01:37Neural Regulation
39.8K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
39.8K