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Preparation and Evaluation of Animal Models of Cardiotoxicity in Antineoplastic Therapy
Chenchen Meng1,2, Lu Fan1,2, Xiaoming Wang1,2
1First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
Abstract:
The continuous development of antineoplastic therapy has significantly reduced the mortality of patients with malignant tumors, but its induced cardiotoxicity has become the primary cause of long-term death in patients with malignant tumors. However, the pathogenesis of cardiotoxicity of antineoplastic therapy is currently unknown, and practical means of prevention and treatment are lacking in clinical practice. Therefore, how to effectively prevent and treat cardiotoxicity while treating tumors is a major challenge. Animal models are important tools for studying cardiotoxicity in antitumor therapy and are of great importance in elucidating pathophysiological mechanisms and developing and evaluating modality drugs. In this paper, we summarize the existing animal models in antitumor therapeutic cardiotoxicity studies and evaluate the models by observing the macroscopic signs, echocardiography, and pathological morphology of the animals, aiming to provide a reference for subsequent experimental development and clinical application.
Insights
Antineoplastic therapy improves cancer survival but causes cardiotoxicity, a leading cause of death. This review evaluates animal models for studying and combating this crucial side effect.
Area of Science:
- Oncology
- Cardiology
- Toxicology
Background:
- Antineoplastic therapies have improved cancer survival rates.
- However, cancer treatment-induced cardiotoxicity is a significant cause of long-term mortality.
- The mechanisms of cardiotoxicity remain largely unknown, with limited clinical prevention and treatment strategies.
Purpose of the Study:
- To review and evaluate existing animal models for studying cardiotoxicity induced by antineoplastic therapy.
- To provide a reference for future research and clinical applications in this field.
Main Methods:
- Systematic review of literature on animal models used in cardiotoxicity studies.
- Evaluation of models based on macroscopic signs, echocardiography, and pathological morphology.
- Assessment of the utility of each model in elucidating pathophysiological mechanisms and drug development.
Main Results:
- Identified and categorized various animal models used in cardiotoxicity research.
- Assessed the strengths and limitations of each model in mimicking human responses.
- Highlighted the importance of standardized evaluation metrics for model comparison.
Conclusions:
- Animal models are essential for understanding antineoplastic therapy-induced cardiotoxicity.
- Careful selection and evaluation of models are crucial for successful research and development of countermeasures.
- Further research is needed to refine existing models and develop new ones for better clinical translation.
