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Related Experiment Videos

Low serum B12 levels in a hematologically normal elderly subpopulation.

D L Marcus, N Shadick, J Crantz

    Journal of the American Geriatrics Society
    |July 1, 1987
    PubMed
    Summary

    Elderly individuals often show altered Vitamin B12 transport. This study found changes in transcobalamin II (TC II)-B12 delivery systems in older adults, impacting B12 availability.

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    Area of Science:

    • Gerontology
    • Nutritional Biochemistry
    • Hematology

    Background:

    • Serum Vitamin B12 levels are crucial for health, especially in the elderly.
    • Age-related changes in nutrient metabolism and transport are common.
    • Vitamin B12 deficiency can lead to various health issues.

    Purpose of the Study:

    • To investigate serum Vitamin B12 levels in an elderly population.
    • To examine the role of B12 binding proteins, specifically transcobalamins (TC), in the elderly.
    • To identify alterations in the B12 transport system in aging individuals.

    Main Methods:

    • Serum Vitamin B12 levels were measured in 378 elderly patients (56-104 years) using a radiodilution method.
    • B12 binding proteins (TC I, II, and III) were quantified using QUSO and DEAE cellulose batch separations.

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  • Analysis of TC II binding sites and B12 saturation levels was performed.

    • Main Results:

    • 26 out of 378 elderly patients had low serum B12 levels; 19 were asymptomatic and hematologically normal.
    • Elevated TC II binding/affinity sites for B12 were observed in both normal and low B12 elderly groups.
    • A significant decrease in the percentage of total serum B12 carried by TC II (from 17% in controls to 4% in elderly) was noted, with increased TC II unsaturation.

    Conclusions:

    • The elderly exhibit an altered Vitamin B12 transport system, particularly involving TC II.
    • Changes in the TC II-B12 delivery system may contribute to altered B12 status in aging individuals.
    • Further research is needed to understand the clinical implications of these findings.