Related Experiment Video

Updated: Sep 4, 2025

Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome
06:39

Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome

Published on: October 3, 2018

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Risk factors for cardiovascular disease mortality in patients with myelodysplastic syndromes: A nationwide,

Konstantinos Liapis1, Georgios Vrachiolias1, Vasileios Papadopoulos1

  • 1Department of Hematology Democritus University of Thrace Medical School Alexandroupolis Greece.

Ejhaem
|July 18, 2022
PubMed

Insights

Cardiovascular disease (CVD) is a leading cause of death in myelodysplastic syndrome (MDS) patients. Lower-risk MDS, older age, prior CVD, and specific treatments predict higher CVD mortality risk.

Area of Science:

  • Hematology
  • Cardiology
  • Oncology

Background:

  • Cardiovascular disease (CVD) is a significant cause of mortality in myelodysplastic syndrome (MDS) patients.
  • Predictors of fatal CVD and the impact of MDS treatments on CVD mortality are not well understood.

Purpose of the Study:

  • To identify predictors of cardiovascular disease (CVD) mortality in patients with myelodysplastic syndrome (MDS).
  • To investigate the influence of MDS-specific treatments on CVD mortality.

Main Methods:

  • Retrospective analysis of 831 myelodysplastic syndrome (MDS) patients with documented causes of death.
  • Statistical analysis to determine independent associations between patient characteristics, treatments, and CVD mortality.

Main Results:

  • Lower-risk myelodysplastic syndrome (MDS), age over 70 years, pre-existing cardiovascular disease (CVD), and treatment with erythropoiesis-stimulating agents were independently associated with increased CVD mortality.
  • Identified key risk factors for fatal CVD in the MDS population.

Conclusions:

  • Simple risk factors can predict cardiovascular disease (CVD) mortality in myelodysplastic syndrome (MDS) patients.
  • Findings may enhance clinician awareness of CVD complications and guide early preventive strategies in MDS patients.

Keywords:
cardiovascular diseasecoronary heart diseasedeatherythropoiesis‐stimulating agentsmortalitymyelodysplastic syndromes

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