Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Glaucoma: Overview

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

MAP1S limits autoimmune uveitis by suppressing Th17 differentiation through dual control of the EGR2-LCN2 axis and autophagic flux.

Autophagy·2026

Same author

Gamabufotalin suppresses pancreatic cancer through redox-homeostasis disruption by G6PD downregulation.

Journal of translational medicine·2026

Same author

Squalene in <i>Camellia oleifera</i>: Biosynthetic Pathways, Regulatory Networks, and Functional Perspectives.

Plants (Basel, Switzerland)·2026

Same author

A multicenter, clinically interpretable prediction model for malignancy risk in C-TIRADS 3-4 thyroid nodules.

Frontiers in oncology·2026

Same author

Sacituzumab tirumotecan plus pembrolizumab versus pembrolizumab in PD-L1-positive advanced non-small-cell lung cancer (OptiTROP-Lung05): interim analysis of a randomised, open-label, phase 3 trial.

Lancet (London, England)·2026

Same author

CGHNet: Cross-Guided 2D-3D Hybrid Network with attention mechanism for focal liver lesion classification.

Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society·2026

Search research articles

Related Experiment Video

Updated: Sep 4, 2025

Experimental Glaucoma Induced by Ocular Injection of Magnetic Microspheres

Experimental Glaucoma Induced by Ocular Injection of Magnetic Microspheres

Published on: February 2, 2015

Implicating Causal Brain Magnetic Resonance Imaging in Glaucoma Using Mendelian Randomization.

Kangcheng Liu^1,2,3,4, Pengfei Wu⁵, Bolin Chen^1,2,3

¹Eye Center of Xiangya Hospital, Central South University, Changsha, China.

Frontiers in Medicine

|July 18, 2022

Summary

Brain changes like fornix and uncinate fasciculus degeneration may increase glaucoma risk. Conversely, damage to the right ventral diencephalon and brain stem is linked to higher glaucoma incidence, supporting a brain-eye axis.

Keywords:

Mendelian randomization diffusion tensor imaging glaucoma region-of-interest white matter

More Related Videos

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Published on: February 15, 2022

A Magnetic Microbead Occlusion Model to Induce Ocular Hypertension-Dependent Glaucoma in Mice

A Magnetic Microbead Occlusion Model to Induce Ocular Hypertension-Dependent Glaucoma in Mice

Published on: March 23, 2016

Related Experiment Videos

Last Updated: Sep 4, 2025

Experimental Glaucoma Induced by Ocular Injection of Magnetic Microspheres

Experimental Glaucoma Induced by Ocular Injection of Magnetic Microspheres

Published on: February 2, 2015

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Published on: February 15, 2022

A Magnetic Microbead Occlusion Model to Induce Ocular Hypertension-Dependent Glaucoma in Mice

A Magnetic Microbead Occlusion Model to Induce Ocular Hypertension-Dependent Glaucoma in Mice

Published on: March 23, 2016

Area of Science:

Neuroscience
Ophthalmology
Genetics

Background:

Glaucoma, a neurodegenerative disease, is hypothesized to originate in the brain but manifests in the eyes.
Primary brain changes in glaucoma patients lack definitive evidence.
Mendelian randomization (MR) is employed to investigate the causal link between brain alterations and glaucoma.

Purpose of the Study:

To explore the causal effect of specific brain alterations on the risk of developing glaucoma.
To identify potential brain regions or white matter tracts associated with glaucoma development.
To investigate the existence of a brain-eye axis in the context of glaucoma.

Main Methods:

Utilized summary statistics from genome-wide association studies (GWAS) for diffusion tensor imaging (DTI) measurements and brain region volumes.
Included data from 17,706 individuals for white matter tracts and 19,629 for brain region volumes.
Applied multiplicative random effects inverse variance weighted (IVW) method, validated by MR Egger and weighted median methods, with sensitivity analyses.

Main Results:

Genetic liability to reduced fractional anisotropy in the fornix (FX.FA) and uncinate fasciculus (UNC.FA) was associated with a lower risk of glaucoma.
Enlargement of the right ventral diencephalon and brain stem volumes was linked to an increased risk of glaucoma.
No significant heterogeneity or pleiotropy was detected, strengthening the findings.

Conclusions:

Degeneration of the fornix and uncinate fasciculus, along with injuries to the right ventral diencephalon and brain stem, may increase glaucoma occurrence.
These findings support the concept of a brain-eye axis, where central nervous system changes influence ocular health.
The study provides evidence for brain alterations as potential causal factors in glaucoma development.