Comprehensive Pan-Cancer Analysis of TRPM8 in Tumor Metabolism and Immune Escape
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Published on: September 15, 2023
Wei Zhang1,2, Xin-Yu Qiao1, Qian Li1
1Cell Biology Department, Wuxi School of Medicine, Jiangnan University, Wuxi, China.
Background:
Transient receptor potential melastatin 8 (TRPM8) modulates tumor biology and sensitivity to treatment. The present study aimed to determine the part it plays in tumor immunity and physiology using pan-cancer analysis.
Method:
Data from the GTEx, CCLE, TISIDB, GSCA, cBioportal, and TCGA databases were collected using Estimate, Scanneo, and GSEA, and the associations between TRPM8 and prognosis, molecular subtypes, mutational burden, microsatellite instability, immune gene functions, and drug sensitivity were analyzed in 33 tumor types.
Result:
TRPM8 levels were found to be elevated in most tumors, particularly in solid tumors, with variations according to clinical stage. Mutation frequency was greatest in endometrial carcinoma. High levels of TRPM8 were linked to unfavorable prognosis, immune cell infiltration, and the tumor microenvironment, as well as correlating with abnormalities in the transcription levels of genes associated with immunity and DNA repair. TRPM8 was also linked to unfavorable patient outcomes and cancer-associated signaling.
Conclusions:
TRPM8 is strongly associated with tumor physiology and immunity. The Pan-Cancer analysis suggests the potential of TRPM8 as a treatment target or biomarker for determining the prognosis of a specific type of cancer.
Insights
Transient receptor potential melastatin 8 (TRPM8) is elevated in most cancers and linked to poor prognosis and immune cell infiltration. This pan-cancer analysis suggests TRPM8 could be a potential biomarker for cancer prognosis and treatment.
Area of Science:
- Oncology
- Molecular Biology
- Immunology
Background:
- Transient receptor potential melastatin 8 (TRPM8) is implicated in modulating tumor biology and treatment sensitivity.
- Its role in tumor immunity and physiology requires further investigation.
Purpose of the Study:
- To investigate the role of TRPM8 in tumor immunity and physiology.
- To analyze the association of TRPM8 with various cancer characteristics using a pan-cancer approach.
Main Methods:
- Utilized data from GTEx, CCLE, TISIDB, GSCA, cBioportal, and TCGA databases.
- Employed Estimate, Scanneo, and Gene Set Enrichment Analysis (GSEA) for analysis.
- Examined associations between TRPM8 and prognosis, molecular subtypes, mutational burden, microsatellite instability, immune gene functions, and drug sensitivity across 33 tumor types.
Main Results:
- TRPM8 levels were elevated in most tumors, particularly solid tumors, with clinical stage variations.
- High TRPM8 expression correlated with unfavorable prognosis, increased immune cell infiltration, and altered tumor microenvironment.
- TRPM8 levels were associated with immune and DNA repair gene transcription abnormalities, unfavorable patient outcomes, and cancer-associated signaling.
Conclusions:
- TRPM8 is significantly associated with tumor physiology and immunity.
- Pan-cancer analysis highlights TRPM8's potential as a prognostic biomarker and therapeutic target in various cancers.
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