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Updated: Sep 4, 2025
Full- versus Sub-Regional Quantification of Amyloid-Beta Load on Mouse Brain Sections
Published on: May 19, 2022
Correlation Between Plasma Oligomeric Amyloid-β and Performance on the Language Neutral Visual Cognitive Assessment
Gurveen Kaur Sandhu1, Fatin Zahra Zailan1, Ashwati Vipin1
1Lee Kong Chian School of Medicine, Singapore.
Abstract:
Oligomeric amyloid-β (OAβ), an upstream driver of Alzheimer's disease (AD) neuropathology, correlates with poor cognitive performance and brain volume reduction. Its effect on cognitive performance measured by the language neutral Visual Cognitive Assessment Test (VCAT) remains to be evaluated. We studied the correlation of plasma OAβ with VCAT scores and grey matter volume (GMV) in a Southeast Asian cohort with mild cognitive impairment. Higher plasma OAβ significantly correlated with lower; cognitive scores (VCAT, Mini-Mental State Examination) and GMV/intracranial volume ratio. Such findings reveal the clinical utility of plasma OAβ as a promising biomarker and support validation through longitudinal studies.
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