Recognition of the Multi-class Schizophrenia Based on the Resting-State EEG Network Topology

The clinical therapy of schizophrenia (SCZ) replies on the corresponding accurate and reliable recognition. Although efforts have been paid, the diagnosis of SCZ is still roughly subjective, it is thus urgent to search for related objective physiological parameters. Motivated by the great potential of resting-state networks in underling the brain deficits among different SCZ groups, in this study, we then developed a multi-class feature extraction approach that could effectively extract the spatial network topology and facilitate the recognition of the SCZ, by combining a network structure based supervised learning with an ensemble co-decision strategy. The results demonstrated that the multi-class spatial pattern of the network (MSPN) features outperformed the other conventional electrophysiological features, such as relative power spectrums and network properties, and achieved the highest classification accuracy of 71.58% in the alpha band. These findings did validate that the resting-state MSPN is a promising tool for the clinical assessment of the SCZ.