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Comprehensive Clinical Analysis of Gallbladder Neuroendocrine Neoplasms: A Large-Volume Multicenter Study During One
Yangyang Wang1,2, Bingfeng Huang1, Qihan Fu3,4,5
1Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Annals of Surgical Oncology
|July 18, 2022
Summary
Gallbladder neuroendocrine neoplasms (GB-NENs) are highly malignant with a poor prognosis. This study highlights their characteristics and treatment, emphasizing the need for further research into management strategies.
Area of Science:
- Gastroenterology
- Oncology
- Pathology
Background:
- Gallbladder neuroendocrine neoplasms (GB-NENs) are rare and poorly understood.
- Real-world data on their clinicopathologic features and treatment is limited.
Purpose of the Study:
- To investigate the clinicopathologic characteristics of GB-NENs.
- To analyze the therapeutic situations and outcomes of GB-NENs.
Main Methods:
- A multicenter, large-scale cohort study involving 154 patients with GB-NENs.
- Retrospective analysis of clinicopathologic data and treatment approaches from 2004 to 2021.
Main Results:
- Most GB-NENs were poorly differentiated (62.3%) with a median age of 63 years; 61.7% were female.
- The liver was the most common metastatic site, and pre-operative diagnosis was 100% inaccurate.
- Overall survival rates were 59% at 1 year, 33% at 3 years, and 29% at 5 years.
Conclusions:
- GB-NENs exhibit high malignancy and poor prognosis.
- This study enhances understanding of GB-NENs, informing future research on mechanisms and treatment.
- Further investigation is crucial for optimizing GB-NEN management.
