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Updated: Sep 4, 2025

Laser-induced Breakdown Spectroscopy: A New Approach for Nanoparticle's Mapping and Quantification in Organ Tissue
Published on: June 18, 2014
Visualizing the cerebral distribution of chemical elements: A challenge met with LIBS elemental imaging
Benoit Busser1, Anne-Laure Bulin2, Vincent Gardette3
1Univ. Grenoble Alpes, INSERM U1209, CNRS, UMR 5309, Institute for Advanced Biosciences (IAB), 38000 Grenoble, France; Grenoble Alpes University Hospital, 38700 Grenoble, France; Institut Universitaire de France (IUF), France.
Abstract:
Biological tissues contain various metals and metalloids ions with central role in the regulation of several pathophysiological functions. In parallel, the development and the evaluation of novel nanocompounds for biomedicine require the monitoring of their biodistribution in tissues of interest. Therefore, researchers need to use reliable and accessible techniques to detect and quantify major and trace elements in space-resolved manner. In this communication, we report how Laser-Induced Breakdown Spectroscopy (LIBS) can be used to image the distribution of chemical elements in brain tissues.
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