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Updated: Sep 4, 2025

A Versatile Murine Model of Subcortical White Matter Stroke for the Study of Axonal Degeneration and White Matter Neurobiology
Published on: March 17, 2016
Diffuse subcortical white matter restriction: An uncommon finding on metronidazole toxicity
Mehri Salari1, Masoud Etemadifar2, Helia Ashourizadeh1
1Functional Neurosurgery Research Center, Shohada Tajrish Neurosurgical Center of Excellence, 163038Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Metronidazole, a common antibiotic, can cause serious neurologic disturbances like encephalopathy. This case highlights reversible diffusion-restricted white matter lesions in a young patient, emphasizing careful monitoring during treatment.
Area of Science:
- Neurology
- Infectious Diseases
- Radiology
Background:
- Metronidazole is a widely prescribed antibiotic for various infections.
- Serious neurologic disturbances, including irreversible ones, have been linked to metronidazole use.
- Encephalopathy is a potential adverse effect requiring clinical attention.
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