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Updated: Sep 4, 2025

Intracranial Injection of Adeno-associated Viral Vectors
Published on: November 17, 2010
Transient cryoglobulinaemic vasculitis following ChAdOx1 nCoV-19 vaccine
Sadaf Ahmer1, Jack Bourke2, Nima Mesbah Ardakani2
1Fiona Stanley Hospital, Murdoch, Western Australia, Australia sadaf.ahmer@health.wa.gov.au.
Abstract:
Cryoglobulinaemic vasculitis is an immune-complex-mediated, systemic inflammatory syndrome usually involving small-to-medium vessels due to precipitation of cryoglobulins at <37°C. It can involve any organ but most commonly affects the skin. Associated conditions include infections (hepatitis C and HIV), haematological disorders (chronic lymphocytic lymphoma, monoclonal gammopathy of uncertain significance and multiple myeloma), autoimmune conditions (systemic lupus erythematosus and Sjogren syndrome) or as a complication following vaccination (influenza, pneumococcal and hepatitis B vaccines). Biochemical hallmarks include detection of serum cryoglobulin with low C4 levels. We describe a case of previous healthy patient with transient cryoglobulinaemic vasculitis after first dose of ChAdOx1 nCoV-19 vaccine (AstraZeneca/Oxford).
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