[One new phenylethanoid glycoside from Forsythiae Fructus]
Xin-Jia Yan1, Cheng-Dong Nie2, Yuan-Yuan Jiang2
1Institute of Qinghai-Tibetan Plateau, Southwest Minzu University Chengdu 610041, China Tibetan Plateau Ethnic Medicinal Resources Protection and Utilization Key Laboratory of National Ethnic Affairs Commission of the People's Republic of China Chengdu 610225, China Sichuan Provincial Qiang-Yi Medicinal Resources Protection and Utilization Technology Engineering Laboratory Chengdu 610225, China.
Abstract:
One new phenylethanoid glycoside was isolated from the ethyl acetate fraction of the 75% EtOH extract of Forsythiae Fructus by various column chromatographies(HP20, silica gel, ODS) and preparative HPLC.Its structure was identified as forsythiayanoside E(1) by physicochemical properties and extensive spectroscopic analysis(HR-ESI-MS, 1 D and 2 D NMR).Compound 1 was evaluated for cytotoxic activities by MTT assay and showed weak cytotoxic activity against MCF-7 and A-375 cell lines with inhibition rates of 39.85% and 43.38% at 40 μmol·L~(-1), and no cytotoxic activity against PC-3 and HepG2 cell lines at 100 μmol·L~(-1).
