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Formation of Dispersible Taohong Siwu Tablets
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[Textual research on Wumei Pills].

Shuang-Ying Wang1, Zi-Jing Yang2, Yu-Hang Meng3

  • 1Graduate School, Beijing University of Chinese Medicine Beijing 100029, China.

Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica
|July 19, 2022
PubMed
Summary

Wumei Pills, a traditional Chinese medicine, has a long history and diverse applications. Textual research clarifies its development, composition, and clinical value for various conditions, including digestive and metabolic disorders.

Keywords:
Wumei Pillsclinical applicationhistorical evolutionliterature analysis

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Area of Science:

  • Traditional Chinese Medicine (TCM)
  • Herbal Medicine
  • Pharmacology

Background:

  • Wumei Pills (Wu Mei Wan) is a classical herbal formula originating from the Treatise on Cold Damage (Shang Han Lun).
  • Extensive historical records (102 ancient books, 110 modern studies) document its evolution and therapeutic uses.
  • The formula's composition, indications, and clinical applications have been analyzed across different historical periods.

Purpose of the Study:

  • To conduct comprehensive textual research on Wumei Pills, tracing its historical development and therapeutic applications.
  • To analyze the prescription's origin, composition, dosage, processing, and modern clinical relevance.
  • To provide evidence for further research, development, and rational clinical application of Wumei Pills.

Main Methods:

  • Screening and analysis of 128 historical and modern records pertaining to Wumei Pills.
  • Examination of prescription origin, composition, indications, dosage, medicinal processing, preparation, usage, and contraindications.
  • Review of modern clinical studies focusing on Wumei Pills' applications in various disease systems.

Main Results:

  • Wumei Pills comprises ten key ingredients: Mume Fructus, Asari Radix et Rhizoma, Zingiberis Rhizoma, Coptidis Rhizoma, Angelicae Sinensis Radix, Aconiti Lateralis Radix Praeparata, Zanthoxyli Pericarpium, Cinnamomi Ramulus, Ginseng Radix et Rhizoma, and Phellodendri Chinensis Cortex.
  • Indications have expanded from traditional uses (diarrhea, dysentery, cough) to modern applications in digestive, nervous, endocrine, and metabolic systems (e.g., ulcerative colitis, insomnia, type 2 diabetes mellitus).
  • Dosage has decreased over time, but ingredient proportions remain stable; specific processing is required for Aconiti Lateralis Radix Praeparata and Zanthoxyli Pericarpium, with attention to the toxicity of Asari Radix et Rhizoma.

Conclusions:

  • Wumei Pills demonstrates significant clinical value and a rich historical trajectory.
  • Textual research clarifies its development, supporting evidence-based research and rational clinical use.
  • Understanding the formula's evolution and potential toxicities is crucial for its safe and effective application.