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Achilles Tendon Thickening as a Risk Factor of Cardiovascular Events after Percutaneous Coronary Intervention

Ichiro Matsumoto1, Mizuki Kurozumi1, Tsunetatsu Namba1

  • 1Cardiovascular Center, KKR Takamatsu Hospital.

Journal of Atherosclerosis and Thrombosis
|July 19, 2022
PubMed

Insights

Achilles tendon thickening is common in coronary artery disease patients post-PCI. This condition independently predicts major adverse cardiovascular events, highlighting its clinical significance.

Area of Science:

  • Cardiovascular Medicine
  • Radiology
  • Biomarkers

Background:

  • Achilles tendon thickening is influenced by factors like lipid disorders and age.
  • Coronary artery disease (CAD) patients may exhibit increased Achilles tendon thickness (ATT).
  • Percutaneous coronary intervention (PCI) is a common treatment for CAD.

Purpose of the Study:

  • To determine the prevalence of Achilles tendon thickening in patients with CAD.
  • To investigate the correlation between Achilles tendon thickening and major adverse cardiovascular events (MACE) after PCI.

Main Methods:

  • Retrospective analysis of 887 patients who underwent successful PCI.
  • Measurement of Achilles tendon thickness (ATT) using soft X-ray radiographs.
  • Definition of AT thickening: ATT >8.0 mm (men) and >7.5 mm (women).
  • Follow-up for MACE (cardiovascular mortality, myocardial infarction, revascularization) for up to 5 years.

Main Results:

  • 27.2% of patients exhibited Achilles tendon thickening.
  • Patients with AT thickening had higher low-density lipoprotein cholesterol (LDL-C) levels.
  • Kaplan-Meier analysis showed a significantly higher incidence of MACE in patients with AT thickening.
  • Multivariate analysis confirmed AT thickening as an independent predictor of MACE post-PCI.

Conclusions:

  • Achilles tendon thickening is prevalent in patients with CAD.
  • AT thickening is significantly associated with an increased incidence of MACE after PCI.
  • This association is independent of LDL-C levels.
Abstract

Keywords:
Achilles tendon thickeningFamilial hypercholesterolemiaLDL-cholesterolSecondary prevention

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