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Quantitation of Protein Expression and Co-localization Using Multiplexed Immuno-histochemical Staining and Multispectral Imaging
Published on: April 8, 2016
Multi-scale discriminative network for prostate cancer lesion segmentation in multiparametric MR images
Yatong Liu1, Yu Zhu1,2, Wei Wang3
1School of Information Science and Technology, East China University of Science and Technology, Shanghai, P. R. China.
Purpose:
The accurate and reliable segmentation of prostate cancer (PCa) lesions using multiparametric magnetic resonance imaging (mpMRI) sequences, is crucial to the image-guided intervention and treatment of prostate disease. For PCa lesion segmentation, it is essential to reliably combine local and global information to retain the features of small targets at multiple scales. Therefore, this study proposes a multi-scale segmentation network with a cascading pyramid convolution module (CPCM) and a double-input channel attention module (DCAM) for the automated and accurate segmentation of PCa lesions using mpMRI.
Methods:
First, the region of interest was extracted from the data by clipping to enlarge the target region and reduce the background noise interference. Next, four CPCMs with large convolution kernels in their skip connection paths were designed to improve the feature extraction capability of the network for small targets. At the same time, a convolution decomposition was applied to reduce the computational complexity. Finally, the DCAM was adopted in the decoder to provide bottom-up semantic discriminative guidance; it can use the semantic information of the network's deep features to guide the shallow output of features with a higher discriminant ability. A residual refinement module (RRM) was also designed to strengthen the recognition ability of each stage. The feature maps of the skip connection and the decoder all go through the RRM.
Results:
For the Initiative for Collaborative Computer Vision Benchmarking (I2CVB) dataset, our proposed model achieved a Dice similarity coefficient (DSC) of 79.31% and an average boundary distance (ABD) of 4.15 mm. For the Prostate Multiparametric MRI (PROMM) dataset, our method greatly improved the DSC to 82.11% and obtained an ABD of 3.64 mm.
Conclusions:
The experimental results of two different mpMRI prostate datasets demonstrate that our model is more accurate and reliable on small targets. In addition, it outperforms other state-of-the-art methods.
