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Postproduction Processing of Electrospun Fibres for Tissue Engineering
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Electrospun Antibacterial Composites for Cartilage Tissue Engineering.

Muhammad Samie1,2,3,4,5, Ather Farooq Khan1, John George Hardy3,4

  • 1Interdisciplinary Research Centre in Biomedical Materials, COMSATS University Islamabad, Lahore campus, Lahore, 54000, Pakistan.

Macromolecular Bioscience
|July 19, 2022
PubMed
Summary

Researchers developed electrospun nanofiber mats from poly(ɛ-caprolactone), poly(lactic acid), and silk fibroin for controlled antibiotic release in cartilage repair. These biomaterials show antibacterial activity and cytocompatibility, offering potential for preventing postoperative infections.

Keywords:
antibacterialcartilagecompositedrug deliveryelectrospinning

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Pharmaceutical Sciences

Background:

  • Postoperative infections are a risk in articular cartilage repair.
  • Biomaterials capable of controlled antibacterial release can mitigate this risk.

Purpose of the Study:

  • To create and characterize electrospun nanofiber mats for controlled antibiotic delivery.
  • To evaluate the antibacterial efficacy and cytocompatibility of these novel biomaterials.

Main Methods:

  • Electrospinning of poly(ɛ-caprolactone), poly(lactic acid), and silk fibroin blends.
  • Characterization using scanning electron microscopy, Fourier transform infrared spectroscopy, and tensile testing.
  • In vitro assessment of drug release profiles and antibacterial activity against Staphylococcus aureus and Escherichia coli.

Main Results:

  • Nanofibrous mats with fiber diameters of 324-725 nm were successfully fabricated.
  • Controlled drug release profiles and significant antibacterial activity against Gram-positive and Gram-negative bacteria were observed.
  • Drug-loaded mats demonstrated cytocompatibility comparable to pure poly(ɛ-caprolactone) nanofibers.

Conclusions:

  • Electrospun nanofiber mats show promise for controlled antibiotic release in cartilage repair.
  • These biomaterials possess antibacterial properties and good cytocompatibility.
  • The developed materials have long-term potential for clinical applications in preventing surgical site infections.