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Designing phase I oncology dose escalation using dose-exposure-toxicity models as a complementary approach to

Kristyn Pantoja1,2, Shankar Lanke2, Alain Munafo3

  • 1Department of Statistics, Texas A&M University, College Station, Texas, USA.

CPT: Pharmacometrics & Systems Pharmacology
|July 19, 2022
PubMed
Summary

Bayesian adaptive models using systemic exposure can better estimate the maximum tolerated dose (MTD) in early oncology trials. Incorporating pharmacokinetics improves safety and reliability compared to traditional methods.

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