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Imiquimod-Associated Localized Skin Ulceration in a Patient With Uncontrolled Diabetes
Alexandra H McKinzie1, Megan A Christman
1Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, Indiana.
Background:
Human papillomavirus, one of the most common viral infections worldwide, frequently manifests as condyloma acuminata, or anogenital warts. First-line treatment of this condition includes the use of imiquimod, a topical immunomodulator.
Case:
We describe a case of a localized skin ulceration necessitating surgical debridement after the use of topical imiquimod for 24 hours in a patient with uncontrolled type 2 diabetes mellitus. After debridement, the patient's wound healed appropriately, with regular wound clinic visits and diabetes education.
Conclusion:
Health care professionals should use caution when prescribing imiquimod in patients with uncontrolled type 2 diabetes mellitus.
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