Related Experiment Video

Updated: Sep 4, 2025

Isolation of Atrial Cardiomyocytes from a Rat Model of Metabolic Syndrome-related Heart Failure with Preserved Ejection Fraction
08:31

Isolation of Atrial Cardiomyocytes from a Rat Model of Metabolic Syndrome-related Heart Failure with Preserved Ejection Fraction

Published on: July 26, 2018

10.2K

Cardiac amyloidosis: a review of the literature

Nils de Marneffe1, R Dulgheru2, A Ancion2

  • 1Department of Cardiology, University Hospital of Liege, Liege, Belgium.

Acta Cardiologica
|July 19, 2022
PubMed

Insights

Cardiac amyloidosis, a rare condition, presents with heart failure and requires timely diagnosis through imaging and lab tests. Management focuses on treating symptoms and preventing further amyloid buildup.

Area of Science:

  • Cardiology
  • Internal Medicine
  • Rare Diseases

Background:

  • Cardiac amyloidosis is a rare disease with significant morbidity and mortality.
  • It commonly presents as heart failure with preserved ejection fraction, restrictive cardiomyopathy, or hypertrophic obstructive cardiomyopathy.
  • Key types include light chain (AL), transthyretin (ATTR), and secondary (AA) amyloidosis.

Purpose of the Study:

  • To provide a comprehensive review of the management strategies for cardiac amyloidosis.

Main Methods:

  • Diagnosis relies on imaging (echocardiography, bone scintigraphy, cardiac MRI) and laboratory tests (blood, urine).
  • Tissue biopsy may be required for definitive diagnosis.
  • Treatment involves managing symptoms, complications, and preventing further amyloid deposition.

Main Results:

  • Cardiac amyloidosis can manifest with varied left ventricular characteristics, including preserved ejection fraction and hypertrophy.
  • Multimodality imaging and biochemical analyses are crucial for diagnosis.
  • Therapeutic approaches address both the disease burden and its sequelae.

Conclusions:

  • Effective management of cardiac amyloidosis requires a multi-faceted approach.
  • Early diagnosis and tailored treatment are essential for improving patient outcomes.
  • Ongoing research continues to refine treatment protocols for this complex condition.

Keywords:
Cardiac amyloidosisRestrictive cardiomyopathyTafamidis

More Related Videos

Genetic Analysis of Hereditary Transthyretin Ala97Ser Related Amyloidosis06:33

Genetic Analysis of Hereditary Transthyretin Ala97Ser Related Amyloidosis

Published on: June 9, 2018

7.8K
Isolation and Characterization of Cardiac Mesenchymal Stromal Cells from Endomyocardial Bioptic Samples of Arrhythmogenic Cardiomyopathy Patients09:16

Isolation and Characterization of Cardiac Mesenchymal Stromal Cells from Endomyocardial Bioptic Samples of Arrhythmogenic Cardiomyopathy Patients

Published on: February 28, 2018

7.8K

Related Concept Videos

Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
23
Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
48
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
43
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
30
Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
9.8K
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
20