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Cerebellar voxel-based morphometry in essential tremor.

Alessia Sarica1, Andrea Quattrone2, Marianna Crasà1

  • 1Department of Medical and Surgical Sciences, Neuroscience Research Center, Magna Graecia University, viale Europa, Germaneto, 88100, Catanzaro, Italy.

Journal of Neurology
|July 19, 2022
PubMed
Summary
This summary is machine-generated.

Essential tremor (ET) and resting tremor (rET) patients show mild cerebellar gray matter involvement, particularly in Crus II. In rET, reduced left Crus II volume correlates with altered brainstem excitability.

Keywords:
Blink reflex recovery cycleCerebellumCrusEssential tremorResting tremorVBM

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Area of Science:

  • Neuroimaging
  • Neurology
  • Neuroscience

Background:

  • Conflicting results exist regarding cerebellar gray matter (GM) changes in essential tremor (ET).
  • Large-scale studies on ET patients with resting tremor (rET), characterized by enhanced blink reflex recovery cycle (BRrc), are lacking.

Purpose of the Study:

  • To investigate cerebellar GM differences in ET and rET patients using voxel-based morphometry (VBM).
  • To explore correlations between cerebellar GM volume and BRrc in rET patients.

Main Methods:

  • Seventy ET patients (40 ET, 30 rET) and 39 controls underwent 3T-MRI and BRrc recording.
  • VBM analysis compared cerebellar GM volumes between groups.
  • Linear regression examined the relationship between cerebellar GM volume and the R2 component of BRrc.

Main Results:

  • No significant cerebellar volume differences were found between ET and rET patients or controls individually.
  • VBM analysis of combined ET and rET patients revealed reduced bilateral Crus II GM volumes compared to controls.
  • In rET patients, decreased GM volume in the left Crus II correlated with increased R2BRrc.

Conclusions:

  • ET and rET are distinct tremor syndromes with comparable, mild cerebellar GM involvement.
  • The left Crus II may influence brainstem excitability in rET patients.
  • Further research is warranted to elucidate the cerebellum's role in these tremor syndromes.