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Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

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Published on: November 4, 2010

Precision Medicine in Asthma Therapy.

Stefania Principe^1,2, Susanne J H Vijverberg³, Mahmoud I Abdel-Aziz^3,4

¹Department of Respiratory Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands. s.p.principe@amsterdamumc.nl.

Handbook of Experimental Pharmacology

|July 19, 2022

Summary

Precision medicine advances asthma treatment by identifying biomarkers through omics sciences. This helps select targeted therapies for better disease control in complex asthma cases.

Keywords:

Asthma Biomarkers Omics Precision medicine

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Area of Science:

Pulmonology and Precision Medicine

Background:

Asthma is a complex, heterogeneous respiratory disease requiring personalized evaluation for optimal management.
Severe asthma treatment is evolving with new targeted therapies addressing specific molecular pathways.

Purpose of the Study:

To explore the role of omics sciences in identifying biomarkers for asthma.
To discuss the implications of these biomarkers in guiding precision medicine approaches for asthma therapy.

Main Methods:

Review of current omics techniques (genomics, proteomics, metabolomics, etc.).
Analysis of how these techniques contribute to understanding asthma pathophysiology.
Focus on biomarker discovery for treatment selection and response prediction.

Main Results:

Omics sciences offer powerful tools for dissecting asthma's molecular underpinnings.
Identification of potential biomarkers is crucial for advancing personalized asthma care.
New therapeutic strategies are emerging based on molecular pathway targets.

Conclusions:

Precision medicine, driven by omics data, is revolutionizing asthma treatment.
Biomarker discovery is essential for tailoring therapies to individual asthma patients.
Future research should focus on validating omics-derived biomarkers for clinical application.