Related Experiment Video
Updated: Sep 4, 2025

Author Spotlight: Exploring Salidroside's Molecular Mechanisms in Breast Cancer Treatment
Published on: June 9, 2023
The role of PIP5K1A in cancer development and progression
1Department of Clinical Medicine, Jining Medical University, Jining, 272000, Shandong, China.
Abstract:
Malignant tumors are formed via a pathological process of uncontrolled cell division that seriously endangers human physical and mental health. The PI3K/AKT signaling pathway plays an important role in the occurrence and development of various cancers. As a lipid kinase, PIP5K1A acts on the upstream of the PI3K/AKT signaling pathway and has a variety of biological functions, including cell differentiation, cell migration, and sperm development. An increasing number of studies have shown that the overexpression of PIP5K1A promotes the growth, invasion, and migration of cancer cells, and the inhibition of PIP5K1A can effectively hinder tumor progression. These findings imply that PIP5K1A are potential markers and targets for cancers. The aim of this study was to systemically review the structure and function of PIP5K1A, the relationship between PIP5K1A and tumors and the potential therapeutic value of PIP5K1A inhibitors in cancer. PIP5K1A affects the occurrence and progression of many tumors and will provide new strategies for cancer diagnosis and treatment.
Related Concept Videos
mTOR Signaling and Cancer Progression
The mTOR pathway or the...
PI3K/mTOR/AKT Signaling Pathway
Tumor Progression
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Cancer Cell Migration through Invadopodia
Adaptive Mechanisms in Cancer Cells
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Interactions Between Signaling Pathways
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...

