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Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

16.4K

Natriuretic peptides, extracellular volume, and subclinical cardiovascular changes in chronic kidney disease stages

L Parker Gregg1,2,3, Peter N Van Buren4,5, David J Ramsey3

  • 1Selzman Institute for Kidney Health, Section of Nephrology, Department of Medicine, Baylor College of Medicine, Houston, Texas, USA lucile.gregg@bcm.edu.

Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research
|July 19, 2022
PubMed

Insights

Elevated natriuretic peptides in early chronic kidney disease (CKD) stages 1-3 correlate with cardiovascular changes, not fluid overload. These biomarkers may detect subclinical heart issues in CKD patients.

Area of Science:

  • Nephrology
  • Cardiology
  • Biomarkers

Background:

  • Natriuretic peptide levels are elevated in early chronic kidney disease (CKD) stages 1-3.
  • The association with extracellular volume excess or early cardiovascular changes is unclear.

Purpose of the Study:

  • To investigate cardiovascular changes in patients with CKD stages 1-3.
  • To determine if these changes correlate with brain natriuretic peptide (BNP) and amino-terminal-pro-BNP (NT-pro-BNP) levels and patient-reported symptoms.

Main Methods:

  • Compared cardiovascular parameters (extracellular water, total peripheral resistance index, cardiac index) in CKD stages 1-3 patients and non-CKD controls.
  • Utilized whole-body multifrequency bioimpedance spectroscopy and impedance cardiography.
  • Assessed patient-reported symptoms using questionnaires.

Main Results:

  • CKD patients exhibited higher pulse pressure and total peripheral resistance index, with a lower cardiac index compared to controls.
  • Natriuretic peptides correlated with pulse pressure, cardiac index, and total peripheral resistance index, but not extracellular water.
  • Total peripheral resistance index and blood pressure showed moderate correlation with patient symptoms.

Conclusions:

  • Elevated natriuretic peptides in early CKD may indicate subclinical cardiovascular changes like low cardiac index and elevated peripheral resistance.
  • Further research is needed to explore the role of these biomarkers in detecting early cardiovascular alterations in CKD.

Keywords:
cardiovascular diseasesnatriuretic peptidesrenal insufficiency, chronic

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