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The Glomerular Filtration Rate (GFR) is a measure of kidney function, reflecting the volume of filtrate formed per minute in the kidneys. On average, GFR is approximately 125 mL/min in males and 105 mL/min in females. Maintaining a relatively constant GFR is essential for the kidneys to effectively regulate body fluid homeostasis and maintain extracellular stability.
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Related Experiment Video

Updated: Sep 4, 2025

Using 2-Photon Microscopy to Quantify the Effects of Chronic Unilateral Ureteral Obstruction on Glomerular Processes
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Emerging Insights into Glomerular Vascular Pole and Microcirculation.

Michael S Goligorsky1

  • 1Renal Research Institute, New York Medical College at the Touro University, Valhalla, New York.

Journal of the American Society of Nephrology : JASN
|July 19, 2022
PubMed
Summary

New research reveals a shorter capillary pathway in the kidney

Area of Science:

  • Nephrology
  • Renal Physiology
  • Glomerular Biology

Background:

  • The glomerular vascular pole, regulating renal blood flow, has been extensively studied.
  • Previous research explored signal transduction pathways within the glomerulus.
  • Recent discoveries offer new insights into vascular pole function.

Purpose of the Study:

  • To investigate novel anatomical and functional aspects of the glomerular vascular pole.
  • To propose a new hypothesis regarding glomerular blood flow regulation.

Main Methods:

  • Novel serial section electron microscopy to visualize glomerular microvasculature.
  • Anti-Thy1.1-induced mesangiolysis and intravital microscopy to assess mesangial cell function *in vivo*.
Keywords:
glomerular filtration rateglomerulusmesangial cellsmicrocirculation

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Main Results:

  • Identification of a shorter capillary pathway within the glomerular mesangium.
  • Unequivocal demonstration of mesangial cell contractile function *in vivo*.
  • Mesangial cells can alter glomerular capillary geometry and curvature.

Conclusions:

  • Hypothesized existence of a glomerular perfusion rheostat regulating blood flow.
  • Glomerular Filtration Rate (GFR) is a balance of capillary perfusion states.
  • These findings advance understanding of glomerular microcirculation and glomerulopathies.