Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Negative and Cognitive Symptoms of Schizophrenia01:30

Negative and Cognitive Symptoms of Schizophrenia

116
Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
116
Positive Symptoms of Schizophrenia: Hallucinations and Delusions01:30

Positive Symptoms of Schizophrenia: Hallucinations and Delusions

214
Schizophrenia is a complex mental health disorder that can manifest with various positive symptoms, including thought, movement, and behavior disorders. These symptoms significantly disrupt cognitive and motor functions, leading to profound effects on an individual's ability to engage with the world.
Thought Disorders
Disorganized and unusual thought processes mark thought disorders in schizophrenia. One key feature is disorganized speech, where an individual's conversation includes...
214
Longitudinal Studies01:26

Longitudinal Studies

223
Longitudinal studies are also widely used in other medical and social science fields. For instance, in cardiovascular research, they can monitor patients' health over decades to identify risk factors for heart disease, such as high cholesterol or smoking, and evaluate the long-term effectiveness of preventive measures. Similarly, in mental health studies, researchers might follow individuals from adolescence into adulthood to understand the development and progression of conditions like...
223
Schizophrenia01:17

Schizophrenia

206
Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those...
206
Psychological and Sociocultural Causes of Schizophrenia01:29

Psychological and Sociocultural Causes of Schizophrenia

181
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
181
Language and Cognition01:27

Language and Cognition

431
Language serves as a bridge between ideas and communication, influencing how individuals perceive and interact with the world. Psychologists have long debated whether language shapes thought or vice versa. This discussion gained grip with Edward Sapir and Benjamin Lee Whorf in the 1940s, who proposed that language determines thought, a concept known as linguistic determinism. They suggested that the vocabulary and structure of a language influence how its speakers think and perceive reality.
431

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Associations of local white matter geometry with network efficiency, macrostructural abnormalities, and clinical severity in behavioural variant frontotemporal dementia.

Brain communications·2026
Same author

Speech and Language Markers of Bipolar Disorder: Challenges and Opportunities.

Bipolar disorders·2026
Same author

The functional relevance of a short assessment of formal thought disorder in psychosis.

The British journal of psychiatry : the journal of mental science·2026
Same author

TOPSY: A picture description dataset to examine speech, language and communication in untreated first episode psychosis.

Data in brief·2026
Same author

Reading between the lines: Combining pause dynamics and semantic coherence for automated assessment of thought disorder.

Neuropsychologia·2026
Same author

Increasing participation of people with thought disorder in clinical research.

European psychiatry : the journal of the Association of European Psychiatrists·2026

Related Experiment Video

Updated: Sep 4, 2025

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis
05:52

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis

Published on: November 21, 2013

15.0K

Progressive changes in descriptive discourse in First Episode Schizophrenia: a longitudinal computational semantics

Maria Francisca Alonso-Sánchez1,2, Sabrina D Ford2,3, Michael MacKinley2,3

  • 1CIDCL, Fonoaudiología, Facultad de Medicina, Universidad de Valparaíso, Valparaíso, Chile.

Schizophrenia (Heidelberg, Germany)
|July 19, 2022
PubMed
Summary

Schizophrenia patients show higher speech semantic similarity, linked to cognitive deficits. This pattern persists and changes over time, offering insights into illness progression and cognitive function in schizophrenia.

More Related Videos

Development of a Virtual Reality Assessment of Everyday Living Skills
10:32

Development of a Virtual Reality Assessment of Everyday Living Skills

Published on: April 23, 2014

18.6K
Using the Visual World Paradigm to Study Sentence Comprehension in Mandarin-Speaking Children with Autism
06:15

Using the Visual World Paradigm to Study Sentence Comprehension in Mandarin-Speaking Children with Autism

Published on: October 3, 2018

7.8K

Related Experiment Videos

Last Updated: Sep 4, 2025

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis
05:52

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis

Published on: November 21, 2013

15.0K
Development of a Virtual Reality Assessment of Everyday Living Skills
10:32

Development of a Virtual Reality Assessment of Everyday Living Skills

Published on: April 23, 2014

18.6K
Using the Visual World Paradigm to Study Sentence Comprehension in Mandarin-Speaking Children with Autism
06:15

Using the Visual World Paradigm to Study Sentence Comprehension in Mandarin-Speaking Children with Autism

Published on: October 3, 2018

7.8K

Area of Science:

  • Computational linguistics
  • Psychiatry
  • Cognitive Neuroscience

Background:

  • Computational semantics offers novel methods for analyzing speech in psychiatric disorders.
  • The relationship between semantic speech patterns and illness stage, cognitive deficits, or formal thought disorder in schizophrenia remains unclear.

Purpose of the Study:

  • To investigate if word-level semantic similarity in speech differs between first-episode schizophrenia patients and healthy controls.
  • To determine if semantic similarity tracks cognitive deficits (e.g., Stroop performance, processing speed) and formal thought disorder.
  • To examine the longitudinal changes in semantic similarity over six months and their association with symptom burden.

Main Methods:

  • Collected 1-minute speech samples from 82 individuals (46 first-episode schizophrenia, 36 healthy controls).
  • Utilized co-occurrence based vector embedding to quantify semantic similarity in speech.
  • Gathered six-month follow-up data on a subsample to track changes over time.

Main Results:

  • Patients with schizophrenia exhibited higher semantic similarity at baseline, particularly with impaired social functioning.
  • Higher baseline semantic similarity correlated with poorer Stroop performance and processing speed.
  • Semantic similarity remained stable in healthy controls but increased in schizophrenia patients over six months, linked to negative symptoms.

Conclusions:

  • Speech semantic similarity is a sensitive marker for cognitive and social functioning in early schizophrenia.
  • Changes in semantic similarity over time reflect illness progression and symptom burden.
  • Computational semantic analysis provides valuable insights into the neurobiological underpinnings of schizophrenia.