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Pre-Chiasmatic, Single Injection of Autologous Blood to Induce Experimental Subarachnoid Hemorrhage in a Rat Model
Published on: June 18, 2021
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Long-term vascular events after subarachnoid hemorrhage
Isabel Fernandez-Perez1,2, Eva Giralt-Steinhauer1,2, Elisa Cuadrado-Godia3,4,5
1Neurology Department, Hospital del Mar, Passeig Marítim 25-29, 08003, Barcelona, Spain.
Journal of Neurology
|July 19, 2022
Summary
Long-term vascular event risk after subarachnoid hemorrhage (SAH) is low, but factors like disability and multiple aneurysms predict future events. Identifying these risk factors improves prediction models for SAH survivors.
Area of Science:
- Neurology
- Cardiovascular Research
- Epidemiology
Background:
- The long-term risk of vascular events (VE) following spontaneous subarachnoid hemorrhage (SAH) is not well-established.
- Understanding post-SAH VE incidence and associated risk factors is crucial for patient management.
Purpose of the Study:
- To determine long-term incidence rates of vascular events (VE) in subarachnoid hemorrhage (SAH) survivors.
- To identify factors independently associated with VE risk and assess their predictive utility.
Main Methods:
- A prospective cohort study followed 423 non-fatal SAH patients from 2007-2020, with follow-up until 2021.
- Incidence rates and cumulative incidence at 5 years were calculated.
- Cox regression models and ROC curve analysis were used to identify predictors of VE.
Main Results:
- The incidence rate of VE was 0.020 events per patient-year, with a 5-year cumulative incidence of 11.11%.
- Cerebrovascular events, primarily ischemic, were the most frequent VE.
- Disability post-SAH and multiple aneurysms were independently associated with increased VE risk, enhancing predictive models (AUC increased from 0.679 to 0.764).
Conclusions:
- Vascular risk following subarachnoid hemorrhage (SAH) is relatively low.
- Specific factors related to the SAH event itself, such as disability and aneurysm characteristics, are valuable in identifying high-risk patients for future vascular events.
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