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Acute acalculous cholecystitis following COVID-19 vaccination: a case report

Fabien Mukonki Kyungu1,2, Aude Mukonki Katumba3, Hermann Luhavo Kamwira2

  • 1Unit of Occupational Medicine and Environmental Research, Department of Public Health, Faculty of Medicine, University of Lubumbashi, Lubumbashi, Democratic Republic of the Congo.

The Pan African Medical Journal
|July 20, 2022
PubMed

Insights

The Janssen COVID-19 vaccine may cause acute acalculous cholecystitis, a gallbladder inflammation without stones. This rare adverse event occurred in a young man presenting with abdominal pain and fever post-vaccination.

Area of Science:

  • Gastroenterology
  • Vaccinology
  • Clinical Medicine

Background:

  • Acute acalculous cholecystitis (ACC) typically affects elderly, critically ill patients.
  • ACC is gallbladder inflammation without gallstones.
  • Underlying conditions often predispose patients to ACC.

Observation:

  • A 29-year-old man developed right hypochondrium pain and fever post-Janssen COVID-19 vaccination.
  • Abdominal ultrasound showed gallbladder wall thickening, indicative of ACC.
  • Blood tests revealed thrombocytopenia, eosinophilia, and liver dysfunction.

Findings:

  • The patient's presentation was consistent with acute acalculous cholecystitis.
  • COVID-19 Polymerase Chain Reaction (PCR) test was negative.
  • Treatment included pain management, antibiotics, and fluids, leading to clinical improvement but persistent liver dysfunction.

Implications:

  • The Janssen COVID-19 vaccine is a potential trigger for acute acalculous cholecystitis.
  • This case highlights a possible adverse event following vaccination.
  • Further investigation into vaccine-induced gallbladder inflammation is warranted.

Keywords:
Acute acalculous cholecystitisCOVID-19 vaccinationcase reportliver dysfunction

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