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Extension of the Life Span by Acarbose: Is It Mediated by the Gut Microbiota?
Baiyun Wu1,2, Jiai Yan1,3, Ju Yang1,3
11Nutritional Department, Affiliated Hospital of Jiangnan University, Wuxi, China.
Abstract:
Acarbose can extend the life span of mice through a process involving the gut microbiota. Several factors affect the life span, including mitochondrial function, cellular senescence, telomere length, immune function, and expression of longevity-related genes. In this review, the effects of acarbose-regulated gut microbiota on the life span-influencing factors have been discussed. In addition, a novel theoretical basis for improving our understanding of the mechanisms by which acarbose extends the life span of mice has been suggested.
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