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Updated: Sep 4, 2025

Author Spotlight: Advancements in Molecular Biomarker Testing for Non-Squamous Non-Small Cell Lung Cancer
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Molecular oncology: what is needed to speed access to innovative therapies in clinical research?

Karim Gourari1, Ahmad Awada, Nuria Kotecki

  • 1Oncology Medicine Department, Jules Bordet Institut, Anderlecht, Belgium.

Current Opinion in Oncology
|July 20, 2022
PubMed
Abstract

Insights

New clinical trial designs are needed to accelerate cancer drug development. A patient-centered model aims to improve access to innovative, biomarker-driven treatments for all cancer patients.

Area of Science:

  • Oncology
  • Clinical Trial Design
  • Precision Medicine

Background:

  • Advances in cancer biology have driven molecular and immunological treatments.
  • Biomarker-driven and enrichment designs enhance clinical trial benefits.
  • Increasing molecular subtypes of rare cancers present challenges for drug development.

Purpose of the Study:

  • To review novel approaches for conducting cancer clinical trials.
  • To expedite cancer drug development and enhance patient access to innovation.

Main Methods:

  • Focus on enrichment trial designs based on specific biomarkers or histology.
  • Proposing a new patient-centered model for clinical trial conduct.

Main Results:

  • Enrichment designs show greater potential for demonstrating clinical benefit.
  • A patient-centered model aims to overcome hurdles in rare cancer subtypes.

Conclusions:

  • Innovative strategies are essential for biomarker identification and targeted trials.
  • The proposed model seeks to 'bring the trial to the patient' for broader access.

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