Related Experiment Video
Updated: Sep 4, 2025
08:17
Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy
Published on: June 7, 2015
15.8K
Stereotactic Body Radiotherapy for Locally Advanced Pancreatic Cancer Using Optical Surface Management System -
Hrvoje Kaučić1,2, Domagoj Kosmina3, Dragan Schwarz4,5,6
1Department of Radiosurgery and Radiotherapy, Special Hospital Radiochirurgia Zagreb, Sveta Nedelja, Croatia.
Cancer Management and Research
|July 20, 2022
Summary
Stereotactic body radiotherapy with OSMS-AlignRT in deep breath hold is an effective and safe treatment for locally advanced pancreatic cancer, showing high local control and survival rates with minimal toxicity.
Area of Science:
- Oncology
- Radiation Oncology
- Medical Physics
Background:
- Locally advanced pancreatic cancer (LAPC) presents a significant treatment challenge.
- Stereotactic body radiotherapy (SBRT) offers a potential solution for unresectable cases.
- Accurate tumor targeting and motion management are crucial for effective SBRT in pancreatic cancer.
Purpose of the Study:
- To evaluate the efficacy and safety of SBRT for LAPC.
- To assess the role of Optical Surface Management System - AlignRT (OSMS-AlignRT) for motion management during deep inspiration breath hold (DIBH).
Main Methods:
- Retrospective analysis of 45 LAPC patients treated with SBRT (3-5 fractions, median BED10 79.5 Gy) between April 2017 and December 2020.
- All patients underwent DIBH with OSMS-AlignRT for body surface motion management.
- Primary endpoints: overall survival and local control; secondary endpoints: progression-free survival and toxicity.
Main Results:
- Median follow-up was 15 months.
- One-year local control and overall survival rates were 95.5% and 71.1%, respectively.
- Median progression-free survival was 14 months, with no toxicity greater than Grade 2 observed.
Conclusions:
- SBRT utilizing OSMS-AlignRT in DIBH is an effective and safe local treatment for LAPC.
- This approach demonstrates promising therapeutic potential with acceptable toxicity, suitable for single-modality or multimodal treatment.
- OSMS-AlignRT ensures accurate and reliable motion management during SBRT for pancreatic cancer.
