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Related Experiment Video

Updated: Sep 4, 2025

In Vivo Model for Testing Effect of Hypoxia on Tumor Metastasis
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Latest developments in the pathobiology of Ewing sarcoma.

Irina Karlina1, Brett A Schroeder2, Kirill Kirgizov3

  • 1Group of Experimental Biotherapy and Diagnostics, Institute for Regenerative Medicine, World-Class Research Centre "Digital Biodesign and Personalized Healthcare", I.M. Sechenov First Moscow State Medical University, Moscow 119991, Russia.

Journal of Bone Oncology
|July 20, 2022
PubMed
Summary

Ewing's sarcoma (ES) is a challenging cancer in adolescents. This review highlights key oncogenes driving ES and potential therapeutic targets to overcome drug resistance and improve patient outcomes.

Keywords:
Ewing’s sarcomaOncogenesPathogenesisPediatric oncologyTargeted therapy

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Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Ewing's sarcoma (ES) is an aggressive pediatric cancer.
  • Standard treatments often fail due to drug resistance, leading to disease progression.
  • Unique tumorigenesis mechanisms in ES present opportunities for targeted therapies.

Purpose of the Study:

  • To review clinically relevant oncogenes in Ewing's sarcoma.
  • To discuss their biological roles and connection to treatment-induced stress.
  • To identify candidate targets for novel therapeutic strategies.

Main Methods:

  • Literature review of recent studies on Ewing's sarcoma.
  • Analysis of oncogenic drivers and their impact on tumorigenesis.
  • Identification of potential therapeutic targets based on current research.

Main Results:

  • Several oncogenes play critical roles in ES development and progression.
  • Treatment-induced stress can influence the activity of these oncogenes.
  • Targeting specific oncogenic pathways shows promise for overcoming resistance.

Conclusions:

  • Understanding ES oncogenes is crucial for developing effective treatments.
  • Targeted therapies focusing on oncogenic drivers offer new hope for patients.
  • Further research into these targets may significantly improve ES patient outcomes.