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Biohybrid materials: Structure design and biomedical applications.

Chong Wang1, Zhuohao Zhang1, Jiali Wang1

  • 1Shanghai Xuhui Central Hospital, Zhongshan-Xuhui Hospital, And the Shanghai Key Laboratory of Medical Epigenetics, The International Co-laboratory of Medical Epigenetics and Metabolism (Ministry of Science and Technology), Institutes of Biomedical Sciences, Fudan University, Shanghai, 200032, China.

Materials Today. Bio
|July 20, 2022
PubMed
Summary

Biohybrid materials combine living cells and non-living components for advanced biomimetic properties. This review explores their design, function, and biomedical applications, highlighting their potential in regenerative medicine and beyond.

Keywords:
Biohybrid fiberBiohybrid microcapsuleBiohybrid microgelBiohybrid scaffoldBiohybrid sheet

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Area of Science:

  • Biomaterials Science
  • Cell Biology
  • Medical Engineering

Background:

  • Biohybrid materials integrate living cells with non-living materials.
  • They offer enhanced biocompatibility and programmability compared to conventional materials.
  • These materials can support cell proliferation and enhance cellular functions.

Purpose of the Study:

  • To review the concept and unique features of biohybrid materials.
  • To compare biohybrid materials with conventional materials.
  • To discuss structure-function relationships and biomedical applications.

Main Methods:

  • Literature review focusing on biohybrid material design and applications.
  • Comparative analysis of biohybrid versus conventional materials.
  • Exploration of structure-function relationships in biohybrid systems.

Main Results:

  • Biohybrid materials exhibit unique biomimetic properties and functionalities.
  • Their design and structure are crucial for dictating material function.
  • Promising applications exist across various biomedical frontiers.

Conclusions:

  • Biohybrid materials present novel strategies for addressing biomedical challenges.
  • Further research can foster interdisciplinary communication between cell biology, material sciences, and medical engineering.
  • This field holds significant potential for advancing regenerative medicine and therapeutic strategies.