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Updated: Sep 4, 2025

Isolating Free Carbenes, their Mixed Dimers and Organic Radicals
Published on: April 19, 2019
Radical deuteration
Nian Li1, Yantao Li1, Xiaopeng Wu1
1State Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China. xie@nju.edu.cn.
Abstract:
Deuterated chemicals are becoming irreplaceable in pharmaceutical engineering, material science and synthetic chemistry. Many excellent reviews have discussed acid/base-dependent or metal-catalyzed deuteration reactions, but radical deuterations have been discussed less. With the development of radical chemistry, there has been a rapid growth in radical deuterium-labelling technology. Diverse mild, cheap and efficient strategies for deuterium atom installation have been reported, and this review summarizes the recent achievements of radical deuteration classified by the reaction types.
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