Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Anthrapyridone-based amino acids as colorimetric probes for Cu<sup>2+</sup> ion determination.

Analytical methods : advancing methods and applications·2025
Same author

Fe-Polyphenol Self-Assembled Nanoplatform for Sonodynamic-Ferroptosis-Autophagy Inhibition Synergistic Tumor Therapy.

ACS applied materials & interfaces·2025
Same author

An Asymmetric NIR-II Organic Fluorophore with an Ultra-Large Stokes Shift for Imaging-Guided and Targeted Phototherapy.

ACS biomaterials science & engineering·2024
Same author

J-Aggregation induced NIR-II fluorescence: an aza-BODIPY luminogen for efficient phototheranostics.

Journal of materials chemistry. B·2023
Same author

Exploiting Cancer Vulnerabilities by Blocking of the DHODH and GPX4 Pathways: A Multifunctional Bodipy/PROTAC Nanoplatform for the Efficient Synergistic Ferroptosis Therapy.

Advanced healthcare materials·2023
Same author

Black phosphorus nanosheets/poly(allylamine hydrochloride) based electrochemical immunosensor for the selective detection of human epididymis protein 4.

Nanotechnology·2022

Related Experiment Video

Updated: Sep 4, 2025

A Bright NIR-II Fluorescence Probe for Vascular and Tumor Imaging
05:51

A Bright NIR-II Fluorescence Probe for Vascular and Tumor Imaging

Published on: March 17, 2023

1.9K

An aza-BODIPY-based NIR-II luminogen enables efficient phototheranostics.

Na Yang1,2, Shuang Song2, Chang Liu1,2

  • 1School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei 230026, P.R. China. congyu@ciac.ac.cn.

Biomaterials Science
|July 20, 2022
PubMed
Summary
This summary is machine-generated.

A novel aza-BODIPY fluorescent probe (CB1) offers enhanced second near-infrared (NIR-II) imaging and photothermal therapy for cancer. This probe demonstrates superior performance to indocyanine green (ICG) with minimal side effects.

More Related Videos

Near Infrared Photoimmunotherapy for Mouse Models of Pleural Dissemination
05:39

Near Infrared Photoimmunotherapy for Mouse Models of Pleural Dissemination

Published on: February 9, 2021

3.4K
Tissue-simulating Phantoms for Assessing Potential Near-infrared Fluorescence Imaging Applications in Breast Cancer Surgery
11:05

Tissue-simulating Phantoms for Assessing Potential Near-infrared Fluorescence Imaging Applications in Breast Cancer Surgery

Published on: September 19, 2014

12.3K

Related Experiment Videos

Last Updated: Sep 4, 2025

A Bright NIR-II Fluorescence Probe for Vascular and Tumor Imaging
05:51

A Bright NIR-II Fluorescence Probe for Vascular and Tumor Imaging

Published on: March 17, 2023

1.9K
Near Infrared Photoimmunotherapy for Mouse Models of Pleural Dissemination
05:39

Near Infrared Photoimmunotherapy for Mouse Models of Pleural Dissemination

Published on: February 9, 2021

3.4K
Tissue-simulating Phantoms for Assessing Potential Near-infrared Fluorescence Imaging Applications in Breast Cancer Surgery
11:05

Tissue-simulating Phantoms for Assessing Potential Near-infrared Fluorescence Imaging Applications in Breast Cancer Surgery

Published on: September 19, 2014

12.3K

Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Oncology

Background:

  • High-performance second near-infrared (NIR-II) fluorophores are crucial for precise cancer diagnosis and treatment.
  • Developing NIR-II phototherapeutic agents with excellent imaging and minimal side effects is challenging due to limited fluorophore options.

Purpose of the Study:

  • To design and synthesize a novel NIR-II fluorescent probe for enhanced cancer theranostics.
  • To evaluate the imaging and therapeutic potential of the new probe in preclinical models.

Main Methods:

  • Synthesis of a new NIR-II fluorescent probe, CB1, based on an aza-BODIPY core conjugated with bulky donors.
  • Encapsulation of CB1 in DSPE-PEG2000 to create water-soluble nanoparticles.
  • In vitro and in vivo evaluation of fluorescence imaging, photostability, tissue penetration, photothermal properties, and therapeutic efficacy.

Main Results:

  • CB1 nanoparticles exhibited brighter NIR-II fluorescence and higher photostability compared to indocyanine green (ICG).
  • CB1 nanoparticles demonstrated deep tissue penetration and high in vivo imaging contrast.
  • The probe showed effective tumor growth inhibition with negligible side effects in both in vitro and in vivo studies.

Conclusions:

  • CB1 nanoparticles represent a promising theranostic agent for NIR-II fluorescence imaging and cancer therapy.
  • This work establishes a new platform for developing advanced cancer diagnosis and treatment strategies.