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Updated: Sep 4, 2025
Reconstituting Cytoarchitecture and Function of Human Epithelial Tissues on an Open-Top Organ-Chip
Published on: February 17, 2023
ANISE: an application to design mechanobiology simulations of planar epithelia
Ángel Rodríguez Cerro1, Sergio Sancho1, Míriam Rodríguez1
1Instituto de Robótica y de Tecnologías de la Información y la Comunicación (IRTIC), Universitat de València, C/Catedrático José Beltrán, 2 46980 Paterna (Valencia), Spain.
Summary:
TiFoSi (Tissues Forces & Signaling) is an efficient computational tool for performing mechanobiology simulations of planar epithelia. A drawback of this tool is that it relies on an XML configuration file (input data) that can be cumbersome to set up and/or decode due to the endless possibilities of the software. Moreover, some modeling know-how is needed in order to provide equations that describe gene regulatory interactions. These factors limit the usability of this tool for users with a weak computational and/or mathematical background. Here, we introduce ANISE (grAphical coNfigurator of TiFoSi In Silico Experiments), a web-app that allows to easily setup the configuration of mechanobiology simulations using TiFoSi. The application covers all the configuration modules in TiFoSi comprehensively (from basic to advanced editing options) and uses a graphical approach (e.g. to build the modeling equations of gene regulatory networks).
Availability And Implementation:
http://github.com/lsym-uveg/anise (server: http://lsymserver.uv.es/lsym/ANISE).
