Cyanine-flavonol hybrids as NIR-light activatable carbon monoxide donors in methanol and aqueous solutions
Qiuyun Yang1,2, Lucie Muchová3, Lenka Štacková1,2
1Department of Chemistry, Faculty of Science, Masaryk University, Kamenice 5, 625 00, Brno, Czech Republic. klan@sci.muni.cz.
Abstract:
Here we report on carbon monoxide-photoreleasable compounds (photoCORMs) that combine heptamethine cyanine and flavonol chromophores and are activated upon irradiation with near-infrared light. Excellent CO-release yields and uncaging cross sections in aqueous solutions, enhanced water solubilities thanks to polar substituents or a host-guest approach using cucurbit[7]uril are demonstrated. The hybrids display outstanding biocompatibility and diverse, structure-dependent cell penetrability and internalization.
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