Analysis of multicomponent formulations containing pseudoephedrine HCl and chlorpheniramine maleate using...

Pseudoephedrine HCl and chlorpheniramine maleate are compounds which have overlapping UV spectra in solutions of phosphate buffer (pH 7.2), water, and 0.1 M HCl. The quantitation of both compounds was achieved by using first-derivative spectroscopy on a diode-array spectrophotometer. The application of this method for the analysis of content uniformity testing and measuring dissolution profiles was demonstrated.