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Physiology of the Gastrointestinal System II: Digestion and Absorption01:22

Physiology of the Gastrointestinal System II: Digestion and Absorption

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The gastrointestinal (GI) tract, extending from the mouth to the anus, plays a pivotal role in the digestion and absorption of nutrients. This process involves both mechanical and chemical actions facilitated by various enzymes.
Digestion begins in the mouth, where food undergoes mechanical breakdown by chewing and combines with saliva. Salivary amylase, an enzyme in saliva, starts the breakdown of starches into maltose. The food then travels down the esophagus to the stomach.
In the stomach, a...
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Anatomy of the Intestines01:23

Anatomy of the Intestines

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Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
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Physiology of Enteric Nervous System and Gut Health01:05

Physiology of Enteric Nervous System and Gut Health

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The gastrointestinal tract, responsible for the digestion and absorption of nutrients, is safeguarded by the intestinal barrier, which consists of secretory, physical, and immune components. At the forefront is the secretory barrier, composed of essential elements such as mucus, gut microbiota, and defense proteins. They collaborate to break down food particles, facilitate nutrient absorption, and maintain optimal gut health. These secretory components ensure the smooth functioning of the...
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Neural Regulation01:37

Neural Regulation

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Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
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Major Organs of the Digestive System01:19

Major Organs of the Digestive System

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The digestive system is responsible for the ingestion of food, secretion of enzymes, mixing and digesting food, absorption of the nutrients and defecation. The human digestive system consists of two major parts: the gastrointestinal tract and the accessory digestive organs.
Gastrointestinal tract:
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Physiology of the Gastrointestinal System III: Elimination01:26

Physiology of the Gastrointestinal System III: Elimination

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The gastrointestinal elimination process involves a complex interplay of neural and hormonal mechanisms that coordinate the final waste removal from the body. This intricate operation encompasses the absorption of water and electrolytes, vital for transforming the remaining indigestible food matter into feces. The large intestine is pivotal in water and electrolyte absorption, forming feces from unabsorbed minerals, undigested food, bacteria, bile pigments, and shed epithelial cells. Essential...
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Related Experiment Video

Updated: Sep 4, 2025

A Gut-on-a-Chip Model to Study the Gut Microbiome-Nervous System Axis
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A Gut-on-a-Chip Model to Study the Gut Microbiome-Nervous System Axis

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Beyond the gut.

Irina Leonardi1

  • 1Immunai, New York, NY, USA.

Science (New York, N.Y.)
|July 20, 2022
PubMed
Summary

The study reveals that fungi, known as mycobiota, significantly influence the host

Area of Science:

  • Fungal biology
  • Immunology
  • Neuroscience

Background:

  • The human body hosts a complex community of fungi, termed the mycobiota.
  • Fungal interactions with the host immune system are increasingly recognized.
  • The impact of mycobiota on host behavior remains largely unexplored.

Purpose of the Study:

  • To investigate the role of mycobiota in modulating host immunity.
  • To explore the influence of mycobiota on host behavior.

Main Methods:

  • Utilizing animal models to study fungal-host interactions.
  • Employing immunological assays to assess immune responses.
  • Behavioral tests to quantify changes in host actions.

Main Results:

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  • Mycobiota composition significantly affects immune cell activity.
  • Specific fungal species were found to alter key immune pathways.
  • Fungal presence correlated with measurable changes in host behavior patterns.

Conclusions:

  • The mycobiota plays a crucial role in regulating host immunity.
  • Fungal communities can influence host behavior, suggesting a link between the gut-brain axis and fungal presence.