Relationship Between Systemic Inflammation Index and No-Reflow Phenomenon in Patients With ST-Segment Elevation...

Area of Science:

• Cardiology
• Biomarkers
• Inflammation

Background:

• The no-reflow phenomenon is a critical complication in ST-elevation myocardial infarction (STEMI) management.
• Systemic inflammation plays a significant role in the pathophysiology of STEMI and its complications.

Purpose of the Study:

• To investigate the relationship between the systemic inflammation index (SII) and the no-reflow phenomenon in STEMI patients.
• To compare the predictive capabilities of SII, neutrophil-lymphocyte ratio (NLR), and platelet-lymphocyte ratio (PLR) for no-reflow.

Main Methods:

• A cohort of 785 STEMI patients was analyzed.
• No-reflow was defined using Thrombolysis in Myocardial Infarction (TIMI) flow grade.
• NLR, PLR, and SII levels were measured and compared between patients with and without no-reflow.

Main Results:

• Patients with no-reflow exhibited significantly higher NLR, PLR, and SII levels.
• NLR, PLR, and SII were independently associated with the presence of no-reflow.
• The area under the receiver-operating characteristic curve for SII was significantly higher than for NLR and PLR, indicating superior predictive capacity.

Conclusions:

• SII demonstrates a stronger predictive value for the no-reflow phenomenon in STEMI patients than NLR and PLR.
• Systemic inflammation markers, particularly SII, are valuable in assessing the risk of no-reflow post-STEMI.