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Enzymes flying under the radar: Cryptic METTL3 can persist in knockout cells
1Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut, United States of America.
Plos Biology
|July 20, 2022
Abstract:
The presence of m6A in mRNA of METTL3 knockout cells has long been a point of confusion. In this issue of PLOS Biology, Poh and colleagues reveal alternatively spliced, catalytically active METTL3 isoforms that persist in cells previously thought to lack the enzyme.

