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Association between Atrioventricular Block and Mortality in Primary Care Patients: The CODE Study.
Gabriela Miana de Mattos Paixão1, Emilly M Lima1, André B Quadros2
1Universidade Federal de Minas Gerais, Belo Horizonte, MG - Brasil.
Arquivos Brasileiros De Cardiologia
|July 20, 2022
Summary
Atrioventricular block (AVB) is linked to increased mortality, especially in higher-grade forms. Mobitz type I AVB, however, did not show a significant association with mortality in this large study.
Area of Science:
- Cardiology
- Clinical Electrophysiology
- Public Health
Background:
- Atrioventricular block (AVB) is a condition affecting cardiac electrical conduction.
- Existing data on AVB outcomes are primarily from high-income countries, limiting generalizability to diverse populations like Latinx individuals.
Purpose of the Study:
- To investigate the association between atrioventricular block (AVB) and overall mortality.
- To determine if different types of AVB have varying impacts on survival rates.
Main Methods:
- Analysis of digital electrocardiogram (ECG) data from the CODE study (2010-2017).
- Inclusion of over 1.5 million patients aged 16 years and older.
- Utilized log-normal models and Kaplan-Meier curves to assess the relationship between AVB and mortality.
Main Results:
- A total of 1,557,901 patients were included, with a 3.35% mortality rate over a mean follow-up of 3.7 years.
- Atrioventricular block (AVB) was present in 1.38% of patients.
- Higher degrees of AVB (second and third-degree) were significantly associated with lower survival rates, with third-degree AVB showing the greatest reduction in survival.
Conclusions:
- Atrioventricular block (AVB) is an independent risk factor for overall mortality.
- The association between AVB and mortality varied by type, with Mobitz type I being the exception, not significantly linked to increased mortality.
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