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Updated: Sep 4, 2025

Protein Film Infrared Electrochemistry Demonstrated for Study of H2 Oxidation by a [NiFe] Hydrogenase
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Thioester synthesis by a designed nickel enzyme models prebiotic energy conversion

Anastasia C Manesis1, Alina Yerbulekova1, Jason Shearer2

  • 1The Ohio State Biochemistry Program, The Ohio State University, Columbus, OH 43210.

Proceedings of the National Academy of Sciences of the United States of America
|July 20, 2022
PubMed
Summary

Researchers created an artificial enzyme modeling acetyl-CoA synthase (ACS) to understand carbon-carbon bond formation. This artificial ACS reveals key reaction steps and offers insights for sustainable fuel catalysts.

Keywords:
acetyl coenzyme A synthaseactivated thioesterbioorganometalliccarbon–carbon couplingmetalloprotein design

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