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Thermal Ablation for the Treatment of Abdominal Tumors

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Published on: March 7, 2011

Temperature control and intermittent time-set protocol optimization for minimizing tissue carbonization in microwave

Xiaofei Jin¹, Yu Feng¹, Roujun Zhu¹

¹Department of Biomedical Engineering, College of Automation Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing, China.

International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group

|July 20, 2022

Summary

This summary is machine-generated.

Optimizing microwave ablation (MWA) protocols with pulsed energy and temperature control prevents tissue carbonization. This strategy enhances effective tumor ablation while minimizing inflammatory responses for improved clinical outcomes.

Keywords:

Microwave ablation carbonization temperature thermal phase transition

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Area of Science:

Oncology
Biomedical Engineering
Thermal Medicine

Background:

Microwave ablation (MWA) is a promising tumor treatment.
Tissue carbonization during MWA can cause unwanted inflammatory responses.
Optimizing MWA protocols is crucial for effective and safe tumor ablation.

Purpose of the Study:

To develop an optimized MWA protocol to prevent tissue carbonization.
To achieve effective thermal dose for tumor ablation.
To reduce inflammatory responses associated with MWA.

Main Methods:

Differential scanning calorimetry (DSC) determined thermal phase transitions in porcine liver tissues.
An in-house MWA system with real-time temperature monitoring was used.
Continuous and pulsed microwave deliveries with varying intermittent times were evaluated.

Main Results:

DSC identified an endothermic heat absorption peak at 105°C ± 5°C.
Temperature control (100°C upper, 60°C lower threshold) achieved coagulative necrosis without carbonization.
Optimized intermittent pulsed MWA significantly reduced tissue carbonization.

Conclusions:

A straightforward anti-carbonization strategy for MWA was developed by modulating pulsing mode and intermittent time.
Programmed intermittent pulsing MWA shows potential for clinical application expansion.
This approach enhances MWA safety and efficacy in tumor treatment.