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Adverse Events of DOACs in Children

Alessandra Bosch1, Manuela Albisetti2,3

  • 1Division of Hematology/Oncology, The Hospital for Sick Children, Toronto, ON, Canada.

Frontiers in Pediatrics
|July 21, 2022
PubMed

Insights

Direct oral anticoagulants (DOACs) show promise for treating pediatric venous thromboembolism (VTE). Dabigatran etexilate and rivaroxaban are safe and effective alternatives to traditional anticoagulants in children.

Area of Science:

  • Pediatric Hematology
  • Pharmacology
  • Clinical Trials

Background:

  • Pediatric venous thromboembolism (VTE) incidence is rising.
  • Standard anticoagulants lack pediatric-specific trial data.
  • Direct oral anticoagulants (DOACs) are emerging as alternatives.

Purpose of the Study:

  • To review adverse events (AEs) of DOACs in pediatric VTE treatment.
  • To compare DOAC safety and efficacy against standard anticoagulation.
  • To aid clinical decision-making for pediatric anticoagulation.

Main Methods:

  • Review of clinical trials involving DOACs in pediatric patients.
  • Analysis of reported adverse events (AEs) for specific DOACs.
  • Comparison of DOAC data with standard anticoagulant therapies.

Main Results:

  • Dabigatran etexilate and rivaroxaban demonstrate safety and efficiency in pediatric VTE treatment and prevention.
  • Specific DOACs show a favorable adverse event profile in children.
  • DOACs represent a viable option for pediatric anticoagulation.

Conclusions:

  • DOACs are safe and effective for pediatric VTE treatment and secondary prevention.
  • Adverse event profiles support DOAC use in children.
  • This review aids clinicians in selecting appropriate anticoagulation for pediatric patients.

Keywords:
DOACsadverse eventsbleeding complicationchildrenpediatricserious adverse drug events

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