Retroperitoneal Unicentric Castleman's disease, a case report
Seyed Amir Miratashi Yazdi1, Elham Nazar2
1Department of General Surgery, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Annals of Medicine and Surgery (2012)
|July 21, 2022
Summary
Castleman's disease (CD) is a rare nonmalignant lymphoproliferative disorder. This case highlights hyaline-vascular CD presenting as a solitary abdominal mass, emphasizing the need for pathological assessment.
Area of Science:
- Pathology
- Oncology
- Surgical Oncology
Background:
- Castleman's disease (CD) is a rare lymphoproliferative disorder characterized by enlarged hyperplastic lymphoid tissue.
- It presents with distinct histologic subtypes: hyaline-vascular, plasma cell, and mixed form.
Observation:
- A 31-year-old woman presented with a 3-month history of abdominal pain.
- Imaging revealed a well-defined pancreatic tail mass without invasion.
- Histopathology confirmed hyaline-vascular Castleman's disease, showing lymphoid tissue with vascular proliferation and hyalinization.
Findings:
- Pathological assessment is crucial for diagnosing Castleman's disease.
- Unicentric CD should be considered in the differential diagnosis of solitary abdominal masses.
- Surgical resection is both a diagnostic tool and the primary treatment for ambiguous abdominal masses.
Implications:
- This case underscores the importance of considering Castleman's disease in patients with unexplained abdominal masses.
- Accurate histopathological diagnosis is essential for appropriate management.
- Surgical intervention plays a dual role in diagnosis and treatment for such conditions.
